SIGNIFICANCE OF THE HLA-CW6 ALLELE FOR CHOOSING BIOLOGICAL THERAPY FOR SEVERE PSORIASIS. PILOT STUDY

  • Milda Valatkevičiūtė
  • Akvilė Uždavinytė
  • Vesta Kučinskienė
  • Laimutis Kučinskas
  • Paulius Valiukevičius
  • Skaidra Valiukevičienė
Keywords: psoriasis, HLA-Cw6, anti-TNF-α, ustekinumab

Abstract

Introduction. In different populations (Lithuania and other countries), a case-control study showed a strong link between a patient with the HLA-Cw6 allele and early onset psoriasis. To evaluate the relationship between the frequency of the HLA-Cw6 allele, family history of the disease, and the duration of biologic drug treatment among patients with severe psoriasis, a pilot study was conducted. Materials and methods. Retrospectively, 7 patients from the Lithuanian University of Health Sciences Skin and Venereal Diseases Clinic database (n = 80) was selected. These patients did not respond to treatment with more than one anti-TNF-α biologic and were subsequently treated with the IL 12/23 inhibitor ustekinumab. Results. The duration of psoriasis in patients was >20 years, of which more than half were overweight (71.4%) or obese (28.6%). All HLA-Cw6 (+) patients had a family history of psoriasis compared to HLA-Cw6 (-) subjects. More than half of the subjects 57.1 % (95% CI 15.82–74.96) with the HLA-Cw6 allele (HLA-Cw6 (+)) did not respond to treatment with one or two anti-TNF-α drugs. Conclusions. 57.1% (95% CI 15.82–74.96) HLA-Cw6 allele frequency was common among subjects with severe psoriasis who did not respond to treatment with one or more anti-TNF-α drugs. Screening for the HLA-Cw6 allele
may be useful in selecting the sequene of biological therapy

Author Biographies

Milda Valatkevičiūtė

LSMU Medical Academy Faculty of Medicine, Kaunas, Lithuania

Akvilė Uždavinytė

LSMU Medical Academy Faculty of Medicine, Kaunas, Lithuania

Vesta Kučinskienė

LSMU Medical Academy Department of Skin and Venereal Diseases, Kaunas, Lithuania

Laimutis Kučinskas

LSMU Medical Academy Institute of Biology Systems and Genetic Research, Kaunas, Lithuania

Paulius Valiukevičius

LSMU Medical Academy Faculty of Medicine

Skaidra Valiukevičienė

LSMU Medical Academy Department of Skin and Venereal Diseases, Kaunas, Lithuania

Published
2020-06-21
Section
Scientific articles