RELATIONSHIP BETWEEN COL1A1 GENE POLYMORPHISM AND STRESS URINARY INCONTINENCE AMONG MIDDLE AGE AND OLDER WOMEN (CASE-CONTROL STUDY)

  • Povilas Aniulis Department of Urology, Medical Academy, Lithuanian University of Health Sciences
  • Aurelija Podlipskytė Neuroscience Institute, Medical Academy, Lithuanian University of Health Sciences
  • Alina Smalinskienė nstitute of Microbiology and Virology, Veterinary Academy, Lithuanian University of Health Sciences
  • Rosita Aniulienė Department of Obstetrics and Gynecology, Medical Academy, Lithuanian University of Health Sciences
  • Mindaugas Jievaltas Department of Urology, Medical Academy, Lithuanian University of Health Sciences
DOI: https://doi.org/10.37499/LAG.563
Keywords: COL1A1 gene polymorphism, stress urinary incontinence (SUI), pelvic organ prolapse (POP)

Abstract

The aim of the study. To evaluate the frequency of the polymorphism of the collagen type I alpha-1 COL1A1 (rs1800012) gene and its combinations in the case of stress urinary incontinence in middle age and elderly women. Results. Subjects in the urinary incontinence group had significantly higher body mass index (BMI) and positive family history for urinary incontinence. No reliable association between COL1A1 G> T polymorphism and stress urinary incontinence was observed after multivariate logistic regression and inheritance model and allele genotypes. Conclusion. Summarizing our study, we can conclude that no association between COL1A1 G> T polymorphism and stress urinary incontinence was observed when the inheritance model and allele genotypes were evaluated.

Published
2020-12-29
Issue
Vol 23 No 4 (2020)
Section
Scientific articles