RISK FACTORS OF NEPHROCALCINOSIS IN PRETERM INFANTS. RETROSPECTIVE STUDY

Abstract

Summary. Aim. The aim was to evaluate possible risk factors for nephrocalcinosis development in preterm infants. Methods. This retrospective study included 77 patients which were treated in Neonatology Centre, Vilnius University Hospital Santaros Klinikos from January till October in 2017. Two groups were formed: infants with nephrocalcinosis and control group. Statistical calculations were performed using the SPSS 19th edition. Results. The incidence of nephrocalcinosis was 32.5%. Per analysis, Apgar score at 1 minute (6.6 vs 7.1), Apgar score at 5 minutes after birth (7,9 vs 8,1), lower gestational age (27+3 weeks vs 28+6 weeks), lower birth weight (1,073.6 g vs 1,335.7 g), persistent ductus arteriosus (44% vs 13.5%) and/or chronic lung disease (48% vs 17.31%), the need for long-term respiratory support (33.3 days vs 20.5 days), duration of hospitalization (67 days vs 53.8 days), higher serum alkaline phosphatase levels (544 U/l vs 443.8 U/l) were significantly (p<0.05) associated with nephrocalcinosis. Conclusion. Very preterm and sick infants requiring long-term ventilation, with neonatal lung disease or persistent ductus arteriosus were more likely to have nephrocalcinosis.